<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:0665ceda-2abb-4658-a66c-124f059e28aa,g:1d509d9d-b39d-4d5a-881f-af1aadf359cf-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.bioscrip.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="bios-20220930.xsd#CONDENSEDCONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/CONDENSEDCONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_30ac76be-5bcc-456e-b3d6-faab361069be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_7c9bf7e0-e1c3-476b-8ef3-921d6b0dc936" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30ac76be-5bcc-456e-b3d6-faab361069be" xlink:to="loc_us-gaap_LiabilitiesCurrent_7c9bf7e0-e1c3-476b-8ef3-921d6b0dc936" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_801dbdb5-4563-42b9-b326-1779ebef044e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_30ac76be-5bcc-456e-b3d6-faab361069be" xlink:to="loc_us-gaap_LiabilitiesNoncurrent_801dbdb5-4563-42b9-b326-1779ebef044e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_8732ead2-8860-4d0c-b8e8-824cfe174b82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_8ff9e7f3-e8d5-42dc-a1a6-7d8071bc9549" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8732ead2-8860-4d0c-b8e8-824cfe174b82" xlink:to="loc_us-gaap_AssetsCurrent_8ff9e7f3-e8d5-42dc-a1a6-7d8071bc9549" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsNoncurrent_e5c865f7-93a5-40f5-bbdf-80bd42737a31" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_8732ead2-8860-4d0c-b8e8-824cfe174b82" xlink:to="loc_us-gaap_AssetsNoncurrent_e5c865f7-93a5-40f5-bbdf-80bd42737a31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_a314242e-f2e2-4de4-9bb9-c182f0dcae60" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9dbb0251-cd8a-4e6c-b220-1568d6bd20c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_a314242e-f2e2-4de4-9bb9-c182f0dcae60" xlink:to="loc_us-gaap_StockholdersEquity_9dbb0251-cd8a-4e6c-b220-1568d6bd20c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_8faf793d-5729-40fb-82fe-1a7b6bc673bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_a314242e-f2e2-4de4-9bb9-c182f0dcae60" xlink:to="loc_us-gaap_Liabilities_8faf793d-5729-40fb-82fe-1a7b6bc673bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_28e3eb4a-967f-4800-9b73-f917c9c5488a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_944c8beb-c741-4ad3-918d-173662d00480" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_28e3eb4a-967f-4800-9b73-f917c9c5488a" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_944c8beb-c741-4ad3-918d-173662d00480" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_7ca9b22e-4064-461c-8d0b-b40e7be6ef7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_28e3eb4a-967f-4800-9b73-f917c9c5488a" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_7ca9b22e-4064-461c-8d0b-b40e7be6ef7f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_cfca6223-3910-418a-8f90-e36d746697ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_28e3eb4a-967f-4800-9b73-f917c9c5488a" xlink:to="loc_us-gaap_InventoryNet_cfca6223-3910-418a-8f90-e36d746697ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1e07b483-d670-4b43-9f1a-8daefa5f97a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_28e3eb4a-967f-4800-9b73-f917c9c5488a" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_1e07b483-d670-4b43-9f1a-8daefa5f97a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesNoncurrent_ce635485-977e-428e-990e-002998367724" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_fe3a1b20-bc9f-469a-b349-6626b27b941b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_ce635485-977e-428e-990e-002998367724" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_fe3a1b20-bc9f-469a-b349-6626b27b941b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_ea46aa2a-dda8-42a6-9380-715bd5485b13" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_ce635485-977e-428e-990e-002998367724" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_ea46aa2a-dda8-42a6-9380-715bd5485b13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_afe705f2-23a1-4935-a6fd-c8af4186691b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_ce635485-977e-428e-990e-002998367724" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_afe705f2-23a1-4935-a6fd-c8af4186691b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_81f4cce1-43ca-4686-9399-2648fc82b651" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxLiabilitiesNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesNoncurrent_ce635485-977e-428e-990e-002998367724" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilitiesNet_81f4cce1-43ca-4686-9399-2648fc82b651" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_7ce031a8-3fdb-4fc5-8eb4-87ca7c681b80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_cca2761a-7991-437f-85d1-5aee0e5251cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_7ce031a8-3fdb-4fc5-8eb4-87ca7c681b80" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_cca2761a-7991-437f-85d1-5aee0e5251cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_ede920b9-2e43-4ea0-b1f6-2fb396c76db5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_7ce031a8-3fdb-4fc5-8eb4-87ca7c681b80" xlink:to="loc_us-gaap_AccountsPayableCurrent_ede920b9-2e43-4ea0-b1f6-2fb396c76db5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_74dca993-17c2-4a78-b049-cec6969389c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_7ce031a8-3fdb-4fc5-8eb4-87ca7c681b80" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_74dca993-17c2-4a78-b049-cec6969389c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_AccruedExpensesAndOtherCurrentLiabilities_af7839c0-e361-484b-b479-320b8eab8b37" xlink:href="bios-20220930.xsd#bios_AccruedExpensesAndOtherCurrentLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_7ce031a8-3fdb-4fc5-8eb4-87ca7c681b80" xlink:to="loc_bios_AccruedExpensesAndOtherCurrentLiabilities_af7839c0-e361-484b-b479-320b8eab8b37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_18fa04e0-55c7-494d-8eb1-5559951af136" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_7ce031a8-3fdb-4fc5-8eb4-87ca7c681b80" xlink:to="loc_us-gaap_LongTermDebtCurrent_18fa04e0-55c7-494d-8eb1-5559951af136" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_899229f8-07dc-4c11-a1d8-727e6eed7f12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_97728cba-70e4-42ff-af04-0bcb6a510745" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_899229f8-07dc-4c11-a1d8-727e6eed7f12" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_97728cba-70e4-42ff-af04-0bcb6a510745" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_94d6f5bf-8e11-414d-923c-a873f359f5c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_899229f8-07dc-4c11-a1d8-727e6eed7f12" xlink:to="loc_us-gaap_PreferredStockValue_94d6f5bf-8e11-414d-923c-a873f359f5c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_9fa8ec7e-7ac1-406b-b189-59cc99e8b343" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_899229f8-07dc-4c11-a1d8-727e6eed7f12" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_9fa8ec7e-7ac1-406b-b189-59cc99e8b343" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_891196fa-e94d-4749-97fa-1e6fd9f0b09e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_899229f8-07dc-4c11-a1d8-727e6eed7f12" xlink:to="loc_us-gaap_TreasuryStockCommonValue_891196fa-e94d-4749-97fa-1e6fd9f0b09e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_57a2930b-144e-4caf-b7ee-36b8ad3762a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_899229f8-07dc-4c11-a1d8-727e6eed7f12" xlink:to="loc_us-gaap_CommonStockValue_57a2930b-144e-4caf-b7ee-36b8ad3762a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d328b4b0-ba28-4ebd-9710-c1ec61d3e2c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_899229f8-07dc-4c11-a1d8-727e6eed7f12" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_d328b4b0-ba28-4ebd-9710-c1ec61d3e2c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsNoncurrent_dbbb1f70-d01c-4737-a41e-96eaf16c470f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_01c1c57e-72b2-4bbc-88d0-831fbcba781c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_dbbb1f70-d01c-4737-a41e-96eaf16c470f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_01c1c57e-72b2-4bbc-88d0-831fbcba781c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_FiniteLivedIntangibleAssetsNetExcludingCustomerLists_1f4cef88-d3b4-4ccf-8ba7-d11a42b5ca43" xlink:href="bios-20220930.xsd#bios_FiniteLivedIntangibleAssetsNetExcludingCustomerLists"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_dbbb1f70-d01c-4737-a41e-96eaf16c470f" xlink:to="loc_bios_FiniteLivedIntangibleAssetsNetExcludingCustomerLists_1f4cef88-d3b4-4ccf-8ba7-d11a42b5ca43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_2adb825c-8b51-4b5e-85c2-a01d43a094db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_dbbb1f70-d01c-4737-a41e-96eaf16c470f" xlink:to="loc_us-gaap_Goodwill_2adb825c-8b51-4b5e-85c2-a01d43a094db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_0c37effd-7db5-43ee-8235-65597c7f63e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_dbbb1f70-d01c-4737-a41e-96eaf16c470f" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_0c37effd-7db5-43ee-8235-65597c7f63e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_f4fe2205-cee7-45a5-91f8-e8b0d9be13fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_dbbb1f70-d01c-4737-a41e-96eaf16c470f" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_f4fe2205-cee7-45a5-91f8-e8b0d9be13fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_62cbe12e-f0ab-421b-aa04-b947d0a8264e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_dbbb1f70-d01c-4737-a41e-96eaf16c470f" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_62cbe12e-f0ab-421b-aa04-b947d0a8264e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_FiniteLivedCustomerListsNet_97308cb6-d8ec-417b-95fb-166b089567f0" xlink:href="bios-20220930.xsd#bios_FiniteLivedCustomerListsNet"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsNoncurrent_dbbb1f70-d01c-4737-a41e-96eaf16c470f" xlink:to="loc_bios_FiniteLivedCustomerListsNet_97308cb6-d8ec-417b-95fb-166b089567f0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="bios-20220930.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_3847e05d-5f66-4079-bf81-1dab63b02e46" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_d6797730-9ba4-46f1-97ba-8982cdb913df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_3847e05d-5f66-4079-bf81-1dab63b02e46" xlink:to="loc_us-gaap_GrossProfit_d6797730-9ba4-46f1-97ba-8982cdb913df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_060b7729-25aa-4bf6-86e4-8c2b9130228f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_3847e05d-5f66-4079-bf81-1dab63b02e46" xlink:to="loc_us-gaap_OperatingExpenses_060b7729-25aa-4bf6-86e4-8c2b9130228f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_6b8f22ab-be3f-4c0a-85c4-2344da7ff494" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_80ac664f-da11-49d1-9a7f-499ea52942d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_6b8f22ab-be3f-4c0a-85c4-2344da7ff494" xlink:to="loc_us-gaap_InterestExpense_80ac664f-da11-49d1-9a7f-499ea52942d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNet_b1f83a3c-2881-40e1-874e-cfe45a51f77b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_6b8f22ab-be3f-4c0a-85c4-2344da7ff494" xlink:to="loc_us-gaap_InvestmentIncomeNet_b1f83a3c-2881-40e1-874e-cfe45a51f77b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_0028f9f3-5006-4620-bc2f-bf8c6003837f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_6b8f22ab-be3f-4c0a-85c4-2344da7ff494" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_0028f9f3-5006-4620-bc2f-bf8c6003837f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_cea91754-1764-47b3-a50e-6d9bfeadcff4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_ae399376-b061-4358-90ca-816a2341c73b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_cea91754-1764-47b3-a50e-6d9bfeadcff4" xlink:to="loc_us-gaap_OperatingIncomeLoss_ae399376-b061-4358-90ca-816a2341c73b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_30dcc3b8-c44d-4dba-87cb-44bcd3665218" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeExpenseNonoperatingNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_cea91754-1764-47b3-a50e-6d9bfeadcff4" xlink:to="loc_us-gaap_InterestIncomeExpenseNonoperatingNet_30dcc3b8-c44d-4dba-87cb-44bcd3665218" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2390fb99-57ca-4d63-b22a-6074005cfb82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2baf1a89-4b9e-44a9-8099-d9786e445a6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_2390fb99-57ca-4d63-b22a-6074005cfb82" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_2baf1a89-4b9e-44a9-8099-d9786e445a6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_cc134bc9-8e8a-407a-b082-5e1861db539b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_2390fb99-57ca-4d63-b22a-6074005cfb82" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_cc134bc9-8e8a-407a-b082-5e1861db539b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_9168387e-aa3d-47c2-a773-ba77abc86062" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_51e5ce24-e67b-40d4-8359-4a8845f88a42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_9168387e-aa3d-47c2-a773-ba77abc86062" xlink:to="loc_us-gaap_NetIncomeLoss_51e5ce24-e67b-40d4-8359-4a8845f88a42" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_c863185a-bee1-4b42-a4ed-9dc06c29d559" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_9168387e-aa3d-47c2-a773-ba77abc86062" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_c863185a-bee1-4b42-a4ed-9dc06c29d559" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_5c8cb600-5837-4ea1-bde8-47cffedd26fa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_0ca9821d-49d0-4f2f-8830-1817dd1e123e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_5c8cb600-5837-4ea1-bde8-47cffedd26fa" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_0ca9821d-49d0-4f2f-8830-1817dd1e123e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_fa4a2d6a-6ec2-4b48-b16e-7cc7fdabeef2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_5c8cb600-5837-4ea1-bde8-47cffedd26fa" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_fa4a2d6a-6ec2-4b48-b16e-7cc7fdabeef2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_acba1e84-51af-46c7-ad8d-0147e7b13f36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_ed020697-3856-4c50-8b50-da0365c00960" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_acba1e84-51af-46c7-ad8d-0147e7b13f36" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossAfterReclassificationAndTax_ed020697-3856-4c50-8b50-da0365c00960" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_29e1acc7-192e-4c8f-9953-b917ad9a8328" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_872a546d-6083-40a7-9d85-5fb55a150d6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_29e1acc7-192e-4c8f-9953-b917ad9a8328" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_872a546d-6083-40a7-9d85-5fb55a150d6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_6d84656e-9fef-465d-9cde-6f5f110322df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_29e1acc7-192e-4c8f-9953-b917ad9a8328" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_6d84656e-9fef-465d-9cde-6f5f110322df" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="bios-20220930.xsd#UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/UNAUDITEDCONDENSEDCONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cee8c1a-8d29-43ab-a4f1-daa00d36638f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_6eaf4a0d-38f1-4dda-966c-d5c991297e5e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cee8c1a-8d29-43ab-a4f1-daa00d36638f" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_6eaf4a0d-38f1-4dda-966c-d5c991297e5e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_dcfded93-c177-46db-a1f0-bec5bffb29e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_2cee8c1a-8d29-43ab-a4f1-daa00d36638f" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_dcfded93-c177-46db-a1f0-bec5bffb29e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d2e8d978-a05f-4225-96d4-400ffdb7d564" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_ProceedsFromPaymentsForStockOptionsExercisedRestrictedStockVestedAndTaxWithholding_72c87201-d00a-40e7-9a35-4c60c7c99cbc" xlink:href="bios-20220930.xsd#bios_ProceedsFromPaymentsForStockOptionsExercisedRestrictedStockVestedAndTaxWithholding"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d2e8d978-a05f-4225-96d4-400ffdb7d564" xlink:to="loc_bios_ProceedsFromPaymentsForStockOptionsExercisedRestrictedStockVestedAndTaxWithholding_72c87201-d00a-40e7-9a35-4c60c7c99cbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_e25fd631-c328-4635-bc15-b6349bec7741" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d2e8d978-a05f-4225-96d4-400ffdb7d564" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_e25fd631-c328-4635-bc15-b6349bec7741" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_50f34861-4aac-4f6a-8049-229e1f37db5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDebtExtinguishmentCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d2e8d978-a05f-4225-96d4-400ffdb7d564" xlink:to="loc_us-gaap_PaymentsOfDebtExtinguishmentCosts_50f34861-4aac-4f6a-8049-229e1f37db5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_64c704bf-2687-488f-b126-36b9539d174d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d2e8d978-a05f-4225-96d4-400ffdb7d564" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_64c704bf-2687-488f-b126-36b9539d174d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForDepositsAppliedToDebtRetirements_b2b07b71-1498-46ca-a2b0-c32304ba3666" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForDepositsAppliedToDebtRetirements"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d2e8d978-a05f-4225-96d4-400ffdb7d564" xlink:to="loc_us-gaap_PaymentsForDepositsAppliedToDebtRetirements_b2b07b71-1498-46ca-a2b0-c32304ba3666" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfDebt_e341eefa-8a62-4200-9f4d-5355c9768b2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RepaymentsOfDebt"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d2e8d978-a05f-4225-96d4-400ffdb7d564" xlink:to="loc_us-gaap_RepaymentsOfDebt_e341eefa-8a62-4200-9f4d-5355c9768b2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromWarrantExercises_d4680797-be5c-45fc-9b6d-979dca136d26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromWarrantExercises"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_d2e8d978-a05f-4225-96d4-400ffdb7d564" xlink:to="loc_us-gaap_ProceedsFromWarrantExercises_d4680797-be5c-45fc-9b6d-979dca136d26" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_ac8d9d38-967d-4818-8daf-1775ae060973" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_NetIncomeLoss_ac8d9d38-967d-4818-8daf-1775ae060973" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAmortizationAndAccretionNet_9f7d990f-a0c5-48f0-a142-52c3d3033b5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationAmortizationAndAccretionNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_DepreciationAmortizationAndAccretionNet_9f7d990f-a0c5-48f0-a142-52c3d3033b5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_380234f5-5687-4400-92e9-af4dbdfb4f4f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_380234f5-5687-4400-92e9-af4dbdfb4f4f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_6a2bc343-3b82-4763-be38-b18375a2123f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_6a2bc343-3b82-4763-be38-b18375a2123f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_b206665d-bb76-4e15-bfa7-e08fd909f66d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_b206665d-bb76-4e15-bfa7-e08fd909f66d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_b4c9b514-3929-45d7-b4c1-8014bd77ac20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_b4c9b514-3929-45d7-b4c1-8014bd77ac20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_825443ee-eff5-4a68-ae09-d905fa95623d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_ShareBasedCompensation_825443ee-eff5-4a68-ae09-d905fa95623d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_3f9983bb-d6a4-46d8-a9eb-dc998a4e8f20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_OtherOperatingActivitiesCashFlowStatement_3f9983bb-d6a4-46d8-a9eb-dc998a4e8f20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInReceivables_47fe17f8-7af3-4947-91ff-b8c0f8e69807" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInReceivables"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_IncreaseDecreaseInReceivables_47fe17f8-7af3-4947-91ff-b8c0f8e69807" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_5c286a2f-faf7-4f85-acf4-1898bdf837d6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_5c286a2f-faf7-4f85-acf4-1898bdf837d6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_62cccbec-27cd-462f-be16-639548909c96" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_62cccbec-27cd-462f-be16-639548909c96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_f4240429-90b9-45c9-a1e9-ec10678b056d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayableTrade"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableTrade_f4240429-90b9-45c9-a1e9-ec10678b056d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_67bdc181-0966-4fd0-b644-d9b4377ec646" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_IncreaseDecreaseInEmployeeRelatedLiabilities_67bdc181-0966-4fd0-b644-d9b4377ec646" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_1105ca6c-0793-4714-879b-5f664d6c53ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_1105ca6c-0793-4714-879b-5f664d6c53ec" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasePayments_ef3b7b1b-0158-44d1-8785-a666526722c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeasePayments"/>
    <link:calculationArc order="15" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_OperatingLeasePayments_ef3b7b1b-0158-44d1-8785-a666526722c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssetsAndLiabilitiesNet_d58365f3-8d0f-41bf-9e5d-a0089ed3efe8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssetsAndLiabilitiesNet"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssetsAndLiabilitiesNet_d58365f3-8d0f-41bf-9e5d-a0089ed3efe8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_8ba3606a-867d-4e56-8c54-34d03ae1c88e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:calculationArc order="17" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_8ba3606a-867d-4e56-8c54-34d03ae1c88e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentDividendsOrDistributions_d7962a2b-ff68-45a9-a7ee-9408838259bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityMethodInvestmentDividendsOrDistributions"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_b4de2a80-0d5f-4334-941b-6ffbf6d9ca1d" xlink:to="loc_us-gaap_EquityMethodInvestmentDividendsOrDistributions_d7962a2b-ff68-45a9-a7ee-9408838259bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c9151f50-0479-4caf-a859-b8450caa9284" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_615e188c-9ffc-4e87-a97b-5176b7b517c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c9151f50-0479-4caf-a859-b8450caa9284" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_615e188c-9ffc-4e87-a97b-5176b7b517c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ddde1ed5-3a75-4bc9-8af6-7d3be5e29986" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c9151f50-0479-4caf-a859-b8450caa9284" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ddde1ed5-3a75-4bc9-8af6-7d3be5e29986" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f0999802-29f2-4adc-a1d3-c386349080af" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_c9151f50-0479-4caf-a859-b8450caa9284" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f0999802-29f2-4adc-a1d3-c386349080af" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/BUSINESSCOMBINATIONSANDASSETACQUISITIONSPreliminaryEstimateoftheAllocationConsiderationTransferredDetails" xlink:type="simple" xlink:href="bios-20220930.xsd#BUSINESSCOMBINATIONSANDASSETACQUISITIONSPreliminaryEstimateoftheAllocationConsiderationTransferredDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/BUSINESSCOMBINATIONSANDASSETACQUISITIONSPreliminaryEstimateoftheAllocationConsiderationTransferredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_95723c95-ed0b-4c8d-af81-58a75aae01c7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAcquiredFromAcquisition_6fe1c503-8663-4d67-aaeb-d09a557a5eb1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAcquiredFromAcquisition"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_95723c95-ed0b-4c8d-af81-58a75aae01c7" xlink:to="loc_us-gaap_CashAcquiredFromAcquisition_6fe1c503-8663-4d67-aaeb-d09a557a5eb1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_1d9da7b0-2da7-4fa0-87b5-3d7003c6b8fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_95723c95-ed0b-4c8d-af81-58a75aae01c7" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_1d9da7b0-2da7-4fa0-87b5-3d7003c6b8fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_848be770-e25c-41e5-84c7-450d8ffc0e63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_71f9cccf-5524-4561-94df-f6d70bdfdae6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_848be770-e25c-41e5-84c7-450d8ffc0e63" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_71f9cccf-5524-4561-94df-f6d70bdfdae6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther_e8e81676-32d2-4b15-89f5-c02694e15a03" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_848be770-e25c-41e5-84c7-450d8ffc0e63" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesOther_e8e81676-32d2-4b15-89f5-c02694e15a03" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_b6a80517-d535-4a43-9e7e-5a7cf5eb3440" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_848be770-e25c-41e5-84c7-450d8ffc0e63" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_b6a80517-d535-4a43-9e7e-5a7cf5eb3440" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_7008f218-facd-4c63-bd2e-8b9ff7e9cf21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_848be770-e25c-41e5-84c7-450d8ffc0e63" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_7008f218-facd-4c63-bd2e-8b9ff7e9cf21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_2ab7e742-09a3-4a78-8a01-e2d75af7c79a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_848be770-e25c-41e5-84c7-450d8ffc0e63" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_2ab7e742-09a3-4a78-8a01-e2d75af7c79a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_42d10419-4e38-42f4-b248-3754a6f24a54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_848be770-e25c-41e5-84c7-450d8ffc0e63" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_42d10419-4e38-42f4-b248-3754a6f24a54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedCompensation_8449fee9-0ebd-4232-83f3-64dbcb6df66d" xlink:href="bios-20220930.xsd#bios_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedCompensation"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_848be770-e25c-41e5-84c7-450d8ffc0e63" xlink:to="loc_bios_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAccruedCompensation_8449fee9-0ebd-4232-83f3-64dbcb6df66d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/EARNINGSPERSHAREScheduleofBasicandDilutedEarningsLossDetails" xlink:type="simple" xlink:href="bios-20220930.xsd#EARNINGSPERSHAREScheduleofBasicandDilutedEarningsLossDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/EARNINGSPERSHAREScheduleofBasicandDilutedEarningsLossDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_454b9f66-8523-4eef-bb10-83319f2f3b50" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_8b1417f3-4d77-4e8d-83cf-5ddcfd70a1f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_454b9f66-8523-4eef-bb10-83319f2f3b50" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_8b1417f3-4d77-4e8d-83cf-5ddcfd70a1f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_ce288374-4ee2-4157-ae3a-459ec6b28877" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_454b9f66-8523-4eef-bb10-83319f2f3b50" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_ce288374-4ee2-4157-ae3a-459ec6b28877" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/LEASESMaturitiesofLeaseLiabilitiesDetails" xlink:type="simple" xlink:href="bios-20220930.xsd#LEASESMaturitiesofLeaseLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/LEASESMaturitiesofLeaseLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2a33a8a8-bcf7-42b3-9f85-ee3f4bb7d195" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_d1683292-3b3c-4213-856d-f87e8a3a6231" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2a33a8a8-bcf7-42b3-9f85-ee3f4bb7d195" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_d1683292-3b3c-4213-856d-f87e8a3a6231" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_590dc193-8c62-4495-92d4-c963decfd342" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2a33a8a8-bcf7-42b3-9f85-ee3f4bb7d195" xlink:to="loc_us-gaap_OperatingLeaseLiability_590dc193-8c62-4495-92d4-c963decfd342" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/LEASESMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="simple" xlink:href="bios-20220930.xsd#LEASESMaturitiesofLeaseLiabilitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/LEASESMaturitiesofLeaseLiabilitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f1f8cbd6-6dd6-41a3-9831-a9d564378349" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_82adb2ea-62e6-4d4f-95fd-a6a2322cc1b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f1f8cbd6-6dd6-41a3-9831-a9d564378349" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_82adb2ea-62e6-4d4f-95fd-a6a2322cc1b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_63c15fd1-4237-4eaa-abfc-a9646a65d82c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f1f8cbd6-6dd6-41a3-9831-a9d564378349" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_63c15fd1-4237-4eaa-abfc-a9646a65d82c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_3e84dcf2-1a10-4f8c-bf36-d05bfdfcdbcb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f1f8cbd6-6dd6-41a3-9831-a9d564378349" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_3e84dcf2-1a10-4f8c-bf36-d05bfdfcdbcb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_e7fcb8dd-519b-44fb-800b-5852fc9573c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f1f8cbd6-6dd6-41a3-9831-a9d564378349" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_e7fcb8dd-519b-44fb-800b-5852fc9573c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_424a6730-467f-4bff-99dc-4c806e03af80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f1f8cbd6-6dd6-41a3-9831-a9d564378349" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_424a6730-467f-4bff-99dc-4c806e03af80" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_ebd39c4c-509d-4623-867c-fca7f65b49fa" xlink:href="bios-20220930.xsd#bios_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_f1f8cbd6-6dd6-41a3-9831-a9d564378349" xlink:to="loc_bios_LesseeOperatingLeaseLiabilityToBePaidAfterYearFour_ebd39c4c-509d-4623-867c-fca7f65b49fa" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/PROPERTYANDEQUIPMENTDetails" xlink:type="simple" xlink:href="bios-20220930.xsd#PROPERTYANDEQUIPMENTDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/PROPERTYANDEQUIPMENTDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_cd089c56-8554-45ba-8705-33c7d44b6540" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_7443edc4-fda0-4303-bb48-74c1c21ee0b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_cd089c56-8554-45ba-8705-33c7d44b6540" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_7443edc4-fda0-4303-bb48-74c1c21ee0b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_97d94989-5192-479b-84a7-c33e5471834f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_cd089c56-8554-45ba-8705-33c7d44b6540" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_97d94989-5192-479b-84a7-c33e5471834f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/GOODWILLANDOTHERINTANGIBLEASSETSCarryingAmountandAccumulatedAmortizationofIntangibleAssetsDetails" xlink:type="simple" xlink:href="bios-20220930.xsd#GOODWILLANDOTHERINTANGIBLEASSETSCarryingAmountandAccumulatedAmortizationofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/GOODWILLANDOTHERINTANGIBLEASSETSCarryingAmountandAccumulatedAmortizationofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_b1bae820-5a5e-4939-9365-a668ed326df1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_ffffa97d-445e-496e-88c2-c129009429de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_b1bae820-5a5e-4939-9365-a668ed326df1" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_ffffa97d-445e-496e-88c2-c129009429de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_eae4c4e9-8f0f-418a-bfc2-470053e7e7f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_b1bae820-5a5e-4939-9365-a668ed326df1" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_eae4c4e9-8f0f-418a-bfc2-470053e7e7f3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/INDEBTEDNESSDebtDetails" xlink:type="simple" xlink:href="bios-20220930.xsd#INDEBTEDNESSDebtDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/INDEBTEDNESSDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_b304edce-a07e-49b5-ad9e-a36f1aa8a2eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_59d836ae-75e7-467d-8907-566b69e422d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_b304edce-a07e-49b5-ad9e-a36f1aa8a2eb" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_59d836ae-75e7-467d-8907-566b69e422d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_78513e18-3282-4dbb-af11-eab29f7f19a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_b304edce-a07e-49b5-ad9e-a36f1aa8a2eb" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_78513e18-3282-4dbb-af11-eab29f7f19a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_07dc279a-8fd3-4193-8219-062868a09481" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_b304edce-a07e-49b5-ad9e-a36f1aa8a2eb" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_07dc279a-8fd3-4193-8219-062868a09481" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/INDEBTEDNESSDebtDetails_1" xlink:type="simple" xlink:href="bios-20220930.xsd#INDEBTEDNESSDebtDetails_1"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/INDEBTEDNESSDebtDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_a9bb6449-9c65-47a9-9fdc-5010138a01b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_a867a2c2-b604-4eb2-860b-2ca1b7d6ffc0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_a9bb6449-9c65-47a9-9fdc-5010138a01b0" xlink:to="loc_us-gaap_LongTermDebtCurrent_a867a2c2-b604-4eb2-860b-2ca1b7d6ffc0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_7b854e86-df89-49d7-bbef-8aeea3ce287d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_a9bb6449-9c65-47a9-9fdc-5010138a01b0" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_7b854e86-df89-49d7-bbef-8aeea3ce287d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/INDEBTEDNESSLongTermDebtMaturitiesDetails" xlink:type="simple" xlink:href="bios-20220930.xsd#INDEBTEDNESSLongTermDebtMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/INDEBTEDNESSLongTermDebtMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_ff9c9db7-4a42-4d23-b072-315179de1a9c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_401b2ad2-b7a0-4685-baa4-65ec0da15b28" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_ff9c9db7-4a42-4d23-b072-315179de1a9c" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_401b2ad2-b7a0-4685-baa4-65ec0da15b28" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_c340d5ad-0ac4-4e3b-8937-f63429a0e6ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_ff9c9db7-4a42-4d23-b072-315179de1a9c" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_c340d5ad-0ac4-4e3b-8937-f63429a0e6ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_7c2a980a-af51-4a7e-a249-998d95b9eeb2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_ff9c9db7-4a42-4d23-b072-315179de1a9c" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_7c2a980a-af51-4a7e-a249-998d95b9eeb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_388683d7-4c87-4a78-981f-7954453124c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_ff9c9db7-4a42-4d23-b072-315179de1a9c" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_388683d7-4c87-4a78-981f-7954453124c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_75326251-5fae-4d71-9fe3-4f3131a038d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_ff9c9db7-4a42-4d23-b072-315179de1a9c" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_75326251-5fae-4d71-9fe3-4f3131a038d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_bios_LongTermDebtMaturityAfterYearFour_68b97db0-6efb-43d4-994c-53ac2a77ac44" xlink:href="bios-20220930.xsd#bios_LongTermDebtMaturityAfterYearFour"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtInstrumentCarryingAmount_ff9c9db7-4a42-4d23-b072-315179de1a9c" xlink:to="loc_bios_LongTermDebtMaturityAfterYearFour_68b97db0-6efb-43d4-994c-53ac2a77ac44" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.bioscrip.com/role/DERIVATIVEINSTRUMENTSPretaxGainLossonDerivativeInstrumentsDetails" xlink:type="simple" xlink:href="bios-20220930.xsd#DERIVATIVEINSTRUMENTSPretaxGainLossonDerivativeInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.bioscrip.com/role/DERIVATIVEINSTRUMENTSPretaxGainLossonDerivativeInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_1aff6c43-9de6-45d6-b65f-caa6dfae81ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_2dc83d28-673c-4f47-8ad7-99cca3f5e22f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_1aff6c43-9de6-45d6-b65f-caa6dfae81ec" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetInvestmentHedgeGainLossBeforeReclassificationAndTax_2dc83d28-673c-4f47-8ad7-99cca3f5e22f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_ecf37ed4-c037-463a-9a10-d6aea35a60aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet_1aff6c43-9de6-45d6-b65f-caa6dfae81ec" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossCashFlowHedgeGainLossReclassificationBeforeTax_ecf37ed4-c037-463a-9a10-d6aea35a60aa" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
